Nature Communications (Jan 2021)

Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

  • Ditte Demontis,
  • Raymond K. Walters,
  • Veera M. Rajagopal,
  • Irwin D. Waldman,
  • Jakob Grove,
  • Thomas D. Als,
  • Søren Dalsgaard,
  • Marta Ribasas,
  • Jonas Bybjerg-Grauholm,
  • Maria Bækvad-Hansen,
  • Thomas Werge,
  • Merete Nordentoft,
  • Ole Mors,
  • Preben Bo Mortensen,
  • ADHD Working Group of the Psychiatric Genomics Consortium (PGC),
  • Bru Cormand,
  • David M. Hougaard,
  • Benjamin M. Neale,
  • Barbara Franke,
  • Stephen V. Faraone,
  • Anders D. Børglum

Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12


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ADHD is often found to be comorbid with disruptive behavior disorders, but the genetic loci underlying this comorbidity are unknown. Here, the authors have performed a GWAS meta-analysis of ADHD with disruptive behavior disorders, finding three genome-wide significant loci in Europeans, and replicating one in a Chinese cohort.