Nature Communications (Jan 2021)
Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
- Ditte Demontis,
- Raymond K. Walters,
- Veera M. Rajagopal,
- Irwin D. Waldman,
- Jakob Grove,
- Thomas D. Als,
- Søren Dalsgaard,
- Marta Ribasas,
- Jonas Bybjerg-Grauholm,
- Maria Bækvad-Hansen,
- Thomas Werge,
- Merete Nordentoft,
- Ole Mors,
- Preben Bo Mortensen,
- ADHD Working Group of the Psychiatric Genomics Consortium (PGC),
- Bru Cormand,
- David M. Hougaard,
- Benjamin M. Neale,
- Barbara Franke,
- Stephen V. Faraone,
- Anders D. Børglum
Affiliations
- Ditte Demontis
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- Raymond K. Walters
- Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School
- Veera M. Rajagopal
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- Irwin D. Waldman
- Department of Psychology, Emory University
- Jakob Grove
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- Thomas D. Als
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- Søren Dalsgaard
- National Centre for Register-Based Research, Aarhus University
- Marta Ribasas
- Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d’Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona
- Jonas Bybjerg-Grauholm
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- Maria Bækvad-Hansen
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- Thomas Werge
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- Merete Nordentoft
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- Ole Mors
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- Preben Bo Mortensen
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- ADHD Working Group of the Psychiatric Genomics Consortium (PGC)
- Bru Cormand
- Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona
- David M. Hougaard
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- Benjamin M. Neale
- Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School
- Barbara Franke
- Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
- Stephen V. Faraone
- Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University
- Anders D. Børglum
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- DOI
- https://doi.org/10.1038/s41467-020-20443-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
ADHD is often found to be comorbid with disruptive behavior disorders, but the genetic loci underlying this comorbidity are unknown. Here, the authors have performed a GWAS meta-analysis of ADHD with disruptive behavior disorders, finding three genome-wide significant loci in Europeans, and replicating one in a Chinese cohort.
