Evaluation the Role of Preptin Hormone and some Biochemical Parameters in Type2 Diabetic Patients with Cardiovascular disease

Abstract

Background: Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) poses major threat worldwide contributing to excessive morbidity and mortality, these co-morbidities synergistically interact with inflammatory mechanisms. The study aimed to observe levels the Preptin, Lactate dehydrogenase (LDH), Fasting Blood glucose (FBG). Methods: Serum Preptin, LDH and FBG levels were determined in 50 patients with acute myocardial infraction , 50 patients with (type 2 diabetes with myocardial infraction) and 50 healthy subjects. Results: The results show a significant increase in the concentration of serum (Preptin, LDH and FBG) in (T2DM with AMI) group in comparison with the (AMI and controls) groups (p?0.05). But it was found no significant deference in the concentration of serum Preptin and FBG between (AMI and controls) groups (p?0.05). Also it was found no significant deference in the concentration of serum LDH between (AMI with T2DM and AMI) groups (p?0.05). Conclusion: Assessment of preptin with lactate dehydrogenase and fasting glucose may predict pancreatic as well as cardiac dysfunction and its helpful in stratification of severity risk.

Keywords

• Myocardial infraction, Type 2 diabetes, Preptin, Lactate dehydrogenase, Fasting Blood glucose