Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor

Jia Duan; Peiyu Xu; Huibing Zhang; Xiaodong Luan; Jiaqi Yang; Xinheng He; Chunyou Mao; Dan-Dan Shen; Yujie Ji; Xi Cheng; Hualiang Jiang; Yi Jiang; Shuyang Zhang; Yan Zhang; H. Eric Xu

doi:10.1038/s41467-023-36170-3

Nature Communications (Jan 2023)

Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor

Jia Duan,
Peiyu Xu,
Huibing Zhang,
Xiaodong Luan,
Jiaqi Yang,
Xinheng He,
Chunyou Mao,
Dan-Dan Shen,
Yujie Ji,
Xi Cheng,
Hualiang Jiang,
Yi Jiang,
Shuyang Zhang,
Yan Zhang,
H. Eric Xu

Affiliations

Jia Duan: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Peiyu Xu: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Huibing Zhang: Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Xiaodong Luan: Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Jiaqi Yang: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Xinheng He: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Chunyou Mao: Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Dan-Dan Shen: Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Yujie Ji: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Xi Cheng: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Hualiang Jiang: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Yi Jiang: Lingang Laboratory
Shuyang Zhang: Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Yan Zhang: Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
H. Eric Xu: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-023-36170-3
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 12

Abstract

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Follicle stimulating hormone (FSH) is a glycoprotein hormone the functions of which are mediated by a G protein-coupled receptor, FSHR. Here, Duan et al. report cryo-EM structures of FSHR in active and inactive states, suggesting the molecular basis of FSH and small allosteric agonist-mediated FSHR activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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