Nature Communications (Apr 2019)
Mechanical stretch induces hair regeneration through the alternative activation of macrophages
- Szu-Ying Chu,
- Chih-Hung Chou,
- Hsien-Da Huang,
- Meng-Hua Yen,
- Hsiao-Chin Hong,
- Po-Han Chao,
- Yu-Hsuan Wang,
- Po-Yu Chen,
- Shi-Xin Nian,
- Yu-Ru Chen,
- Li-Ying Liou,
- Yu-Chen Liu,
- Hui-Mei Chen,
- Feng-Mao Lin,
- Yun-Ting Chang,
- Chih-Chiang Chen,
- Oscar K. Lee
Affiliations
- Szu-Ying Chu
- Department of Dermatology, Taipei Veterans General Hospital
- Chih-Hung Chou
- Department of Biological Science and Technology, Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Chiao Tung University
- Hsien-Da Huang
- Warshel Institute for Computational Biology, School of Life and Health Sciences, School of Sciences and Engineering, The Chinese University of Hong Kong
- Meng-Hua Yen
- Department of Electronic Engineering, National Chin-Yi University of Technology
- Hsiao-Chin Hong
- Department of Biological Science and Technology, Institute of Bioinformatics and Systems Biology, National Chiao Tung University
- Po-Han Chao
- Institute of Clinical Medicine, National Yang-Ming University
- Yu-Hsuan Wang
- Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong
- Po-Yu Chen
- Department of Dermatology, Taipei Veterans General Hospital
- Shi-Xin Nian
- Department of Dermatology, Taipei Veterans General Hospital
- Yu-Ru Chen
- Institute of Clinical Medicine, National Yang-Ming University
- Li-Ying Liou
- Department of Dermatology, Taipei Veterans General Hospital
- Yu-Chen Liu
- Department of Biological Science and Technology, Institute of Bioinformatics and Systems Biology, National Chiao Tung University
- Hui-Mei Chen
- Department of Biological Science and Technology, Institute of Bioinformatics and Systems Biology, National Chiao Tung University
- Feng-Mao Lin
- Department of Biological Science and Technology, Institute of Bioinformatics and Systems Biology, National Chiao Tung University
- Yun-Ting Chang
- Department of Dermatology, Taipei Veterans General Hospital
- Chih-Chiang Chen
- Department of Dermatology, Taipei Veterans General Hospital
- Oscar K. Lee
- Institute of Clinical Medicine, National Yang-Ming University
- DOI
- https://doi.org/10.1038/s41467-019-09402-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Mechanical stimulation is known to affect cell proliferation, differentiation, and regeneration. Here, the authors demonstrate that stretching mouse skin recruits macrophages and polarizes them into M2 cells that facilitate hair regeneration through the release of growth factors, including HGF and IGF-1
