Single-Dose Intravenous Simvastatin Treatment Attenuates Renal Injury in an Experimental Model of Ischemia-Reperfusion in the Rat

Zorica Nešic; Zoran Todorovic; Radan Stojanovic; Gordana Basta-Jovanovic; Sanja Radojevic-Škodric; Ruzica Velickovic; Prabal K. Chatterjee; Christoph Thiemermann; Milica Prostran

doi:10.1254/jphs.sce06002x

Journal of Pharmacological Sciences (Jan 2006)

Single-Dose Intravenous Simvastatin Treatment Attenuates Renal Injury in an Experimental Model of Ischemia-Reperfusion in the Rat

Zorica Nešic,
Zoran Todorovic,
Radan Stojanovic,
Gordana Basta-Jovanovic,
Sanja Radojevic-Škodric,
Ruzica Velickovic,
Prabal K. Chatterjee,
Christoph Thiemermann,
Milica Prostran

Affiliations

Zorica Nešic: Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Serbia and Montenegro
Zoran Todorovic: Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Serbia and Montenegro
Radan Stojanovic: Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Serbia and Montenegro
Gordana Basta-Jovanovic: Department of Pathology, School of Medicine, University of Belgrade, Serbia and Montenegro
Sanja Radojevic-Škodric: Department of Pathology, School of Medicine, University of Belgrade, Serbia and Montenegro
Ruzica Velickovic: Institute of Mental Health, Laboratory of Biochemistry, Belgrade, Serbia and Montenegro
Prabal K. Chatterjee: School of Pharmacy & Biomolecular Sciences, University of Brighton, Brighton, United Kingdom
Christoph Thiemermann: The William Harvey Research Institute, St. Bartholomew’s and Royal London School of Medicine and Dentistry, London, United Kingdom
Milica Prostran: Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Serbia and Montenegro; Corresponding author. [email protected]

DOI: https://doi.org/10.1254/jphs.sce06002x
Journal volume & issue: Vol. 102, no. 4
pp. 413 – 417

Abstract

Read online

The effect of acute pretreatment with a single dose of simvastatin (1 mg/kg, i.v.; 30 min before ischemia) on renal dysfunction caused by ischemia-reperfusion (I/R) injury in the rat was investigated. I/R injury was induced by clamping both renal vascular pedicles for 45 min, followed by 4 h of reperfusion with saline (2 ml/kg per hour). Simvastatin significantly improved both parameters of glomerular and tubular dysfunction (e.g., creatinine levels and fractional excretion of Na+, respectively) and especially improved the histological score, compared to control I/R-injured rats treated with saline or 10% DMSO only. Keywords:: simvastatin, ischemia-reperfusion renal injury, acute renal failure

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.sciencedirect.com/journal/journal-of-pharmacological-sciences

About the journal