NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development

Joshua Hudson; Sayantanee Paul; Alexey Veraksa; Amin Ghabrial; Kieran F Harvey; Carole Poon

doi:10.1093/g3journal/jkad013

G3: Genes, Genomes, Genetics (Jan 2023)

NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development

Joshua Hudson,
Sayantanee Paul,
Alexey Veraksa,
Amin Ghabrial,
Kieran F Harvey,
Carole Poon

Affiliations

Joshua Hudson: Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia
Sayantanee Paul: Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA
Alexey Veraksa: ORCiD; Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA
Amin Ghabrial: Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Kieran F Harvey: ORCiD; Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia
Carole Poon: Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia

DOI: https://doi.org/10.1093/g3journal/jkad013
Journal volume & issue: Vol. 13, no. 3

Abstract

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AbstractThe Germinal Center Kinase III (GckIII) pathway is a Hippo-like kinase module defined by sequential activation of Ste20 kinases Thousand and One (Tao) and GckIII, followed by nuclear dbf2-related (NDR) kinase Tricornered (Trc). We previously uncovered a role for the GckIII pathway in Drosophila melanogastertrcCerebral cavernous malformations 3Ccm3),Drosophilatrc

Published in G3: Genes, Genomes, Genetics

ISSN: 2160-1836 (Online)
Publisher: Oxford University Press
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General): Genetics
Website: https://academic.oup.com/g3journal

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