Amplification of the MYC Gene in Osteosarcoma Secondary to Paget's Disease of Bone

Takafumi  Ueda; John H. Healey; Andrew G. Huvos; Marc  Ladanyi

doi:10.1080/13577149778209

Sarcoma (Jan 1997)

Amplification of the MYC Gene in Osteosarcoma Secondary to Paget's Disease of Bone

Takafumi Ueda,
John H. Healey,
Andrew G. Huvos,
Marc Ladanyi

Affiliations

Takafumi Ueda: Department of Surgery, Orthopaedic Service, Memorial Sloan-Kettering Cancer Center, New York, USA
John H. Healey: Department of Surgery, Orthopaedic Service, Memorial Sloan-Kettering Cancer Center, New York, USA
Andrew G. Huvos: Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10021, NY, USA
Marc Ladanyi: Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10021, NY, USA

DOI: https://doi.org/10.1080/13577149778209
Journal volume & issue: Vol. 1, no. 3-4
pp. 131 – 134

Abstract

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Purpose. In a previous series of 25 human osteosarcoma samples studied for MYC gene amplification, we found amplification in two cases (8%), including one arising in association with Paget's disease (pagetic osteosarcoma). Based on this observation, we further investigated the prevalence of MYC gene amplification in pagetic osteosarcomas.

Published in Sarcoma

ISSN: 1357-714X (Print); 1369-1643 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://onlinelibrary.wiley.com/journal/5805

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