Turkish Journal of Hematology (Feb 2021)
Current Practice in FFP Preparation and Use in Greece: A National Survey
- Aspasia Argyrou,
- Serena Valsami,
- Abraham Pouliakis,
- Maria Gavalaki,
- Antonis Aggelidis,
- Vasiliki Voulgaridou,
- Vasiliki Pliatsika,
- Theofanis Adraktas,
- Andreas Papachronis,
- Chrysoula Alepi,
- Vasiliki Giannopoulou,
- Panagiotis Siourounis,
- Sofia Tsagia,
- Georges Martinis,
- Eftihia Kontekaki,
- Eleftheria Zervou,
- Spiridon Koliofotis,
- Elias Kyriakou,
- Athina Mougiou,
- Lempousi Dimitra,
- Afrodite Chairopoulou,
- Aggeliki Tsakania,
- Maria Baka,
- Ioanna Apostolidou,
- Dimitra Moschandreou,
- Anastasia Livada,
- Marianna Politou,
- Fragoula Roussinou,
- Christina Pappa,
- Vasiliki Koika,
- Niki Vgontza,
- Anthippi Gafou,
- Ioanna Dendrinou,
- Fotini Sakellaridi,
- Lampothea Labrianou,
- Zafeiria Alexandropoulou,
- Vasiliki Sochali,
- Kostas Malekas,
- Areti Skordilaki,
- Georgia Kakava,
- Konstantinos Lebesopoulos,
- Konstantinos Stamoulis,
- Elisavet Grouzi
Affiliations
- Aspasia Argyrou
- Agioi Anargyroi Hospital, Department of Blood Transfusion, Athens, Greece
- Serena Valsami
- National and Kapodistrian University of Athens, Aretaieion University Hospital, Medical School, Hematology Laboratory-Blood Bank Department, Athens, Greece
- Abraham Pouliakis
- National and Kapodistrian University of Athens, Attikon University Hospital, Second Department of Pathology, Athens, Greece
- Maria Gavalaki
- Laiko General Hospital, Department of Blood Transfusion, Athens, Greece
- Antonis Aggelidis
- Konstantopouleio-Neas Ionias General Hospital, Department of Blood Transfusion, Athens, Greece
- Vasiliki Voulgaridou
- AHEPA, University Hospital, Department of Blood Transfusion, Thessaloniki, Greece
- Vasiliki Pliatsika
- AHEPA, University Hospital, Department of Blood Transfusion, Thessaloniki, Greece
- Theofanis Adraktas
- Laiko General Hospital, Department of Blood Transfusion, Athens, Greece
- Andreas Papachronis
- Laiko General Hospital, Department of Blood Transfusion, Athens, Greece
- Chrysoula Alepi
- General Hospital Tzaneio, Department of Blood Transfusion, Piraeus, Greece
- Vasiliki Giannopoulou
- General Hospital Tzaneio, Department of Blood Transfusion, Piraeus, Greece
- Panagiotis Siourounis
- Agios Panteleimon General Hospital of Nikaia, Department of Blood Transfusion, Athens, Greece
- Sofia Tsagia
- Agios Panteleimon General Hospital of Nikaia, Department of Blood Transfusion, Athens, Greece
- Georges Martinis
- University Hospital, Department of Blood Transfusion, Alexandroupolis, Greece
- Eftihia Kontekaki
- University Hospital, Department of Blood Transfusion, Alexandroupolis, Greece
- Eleftheria Zervou
- University Hospital, Department of Blood Transfusion, Ioannina, Greece
- Spiridon Koliofotis
- Attikon University Hospital, Laboratory of Hematology and Blood Bank Unit, Athens, Greece
- Elias Kyriakou
- Attikon University Hospital, Laboratory of Hematology and Blood Bank Unit, Athens, Greece
- Athina Mougiou
- University Hospital, Blood Transfusion Center, Patras, Greece
- Lempousi Dimitra
- University Hospital, Blood Transfusion Center, Patras, Greece
- Afrodite Chairopoulou
- Sismanogleio General Hospital, Department of Blood Transfusion, Athens, Greece
- Aggeliki Tsakania
- Sismanogleio General Hospital, Department of Blood Transfusion, Athens, Greece
- Maria Baka
- Thriasio General Hospital, Department of Blood Transfusion, Athens, Greece
- Ioanna Apostolidou
- Thriasio General Hospital, Department of Blood Transfusion, Athens, Greece
- Dimitra Moschandreou
- Saint Savvas Oncology Hospital, Department of Blood Transfusion and Clinical Hemostasis, Athens, Greece
- Anastasia Livada
- Saint Savvas Oncology Hospital, Department of Blood Transfusion and Clinical Hemostasis, Athens, Greece
- Marianna Politou
- National and Kapodistrian University of Athens, Aretaieion University Hospital, Medical School, Hematology Laboratory-Blood Bank Department, Athens, Greece
- Fragoula Roussinou
- National and Kapodistrian University of Athens, Aretaieion University Hospital, Medical School, Hematology Laboratory-Blood Bank Department, Athens, Greece
- Christina Pappa
- General Hospital, Department of Blood Transfusion, Korinthos, Greece
- Vasiliki Koika
- General Hospital, Department of Blood Transfusion, Korinthos, Greece
- Niki Vgontza
- Konstantopouleio-Neas Ionias General Hospital, Department of Blood Transfusion, Athens, Greece
- Anthippi Gafou
- Agioi Anargyroi Hospital, Department of Blood Transfusion, Athens, Greece
- Ioanna Dendrinou
- Konstantopouleio-Neas Ionias General Hospital, Department of Blood Transfusion, Athens, Greece
- Fotini Sakellaridi
- General Hospital, Department of Blood Transfusion, Rhodes, Greece
- Lampothea Labrianou
- General Hospital, Department of Blood Transfusion, Rhodes, Greece
- Zafeiria Alexandropoulou
- Asklipieio Voulas General Hospital, Department of Blood Transfusion, Athens, Greece
- Vasiliki Sochali
- General Hospital, Department of Blood Transfusion, Giannitsa, Greece
- Kostas Malekas
- General Hospital, Department of Blood Transfusion, Livadia, Greece
- Areti Skordilaki
- General Hospital, Department of Blood Transfusion, Chania, Greece
- Georgia Kakava
- Pammakaristos General Hospital, Department of Blood Transfusion, Athens, Greece
- Konstantinos Lebesopoulos
- Amalia Fleming General Hospital, Department of Blood Transfusion, Athens, Greece
- Konstantinos Stamoulis
- Hellenic National Blood Transfusion Center, Athens, Greece
- Elisavet Grouzi
- Saint Savvas Oncology Hospital, Department of Blood Transfusion and Clinical Hemostasis, Athens, Greece
- DOI
- https://doi.org/10.4274/tjh.galenos.2020.2020.0241
- Journal volume & issue
-
Vol. 38,
no. 1
pp. 22 – 32
Abstract
Objective: Fresh frozen plasma (FFP) transfusion is widely used in modern clinical settings. Practices regarding its use vary due to lack of guidelines from randomized trials. The aim of this study was to assess both the current practices regarding FFP production, use, and wastage and the implementation of quality control (QC), female donor plasma production policies, and use of pharmaceutical hemostatic agents in Greece. Materials and Methods: The study was conducted during February-April 2018. For the first part of the study, data including FFP transfusion indication, hospital department, diagnosis, FFP units/transfusion episode, ABO compatibility, blood donor's sex, and reasons for discarding were collected. For the second part, questionnaire data were analyzed. Results: According to data from 20 Greek hospitals, 12655 FFP units were transfused to 2700 patients during 5069 transfusion episodes in the studied period of time. Most patients were hospitalized in internal medicine, general surgery, and intensive care unit departments. Each patient received on average 4.69 units (2.5 units/episode). Transfusion requests were in accordance with international guidelines in 63.44% of cases and 99.04% of the units were given to ABO-identical patients. Main reasons for discarding included failure to meet quality requirements (30.06%), female donors (22.17%), and other causes (27.26%). Among 96.9% of all transfusion services across the country, 28.26% perform QC according to the directions of the European Directorate for the Quality of Medicines & Health Care and 68.83% discard plasma from female donors. Pharmaceutic hemostatic agents are used in 37.23% of the hospitals. Conclusion: This is the first national survey regarding FFP production and transfusion in Greece. Staff of internal medicine, general surgery, and ICU departments, where most FFP-transfused patients are hospitalized, should be regularly involved in training on contemporary transfusion guidelines. Upcoming centralization of FFP production and inventory management could help in homogenizing practices regarding FFP use and improve product quality. Strengthening the use of pharmaceutic hemostatic agents could improve patients' management.
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