Antibacterial activity for Tin-cephalexin Schiff bases against Bacillus Pumilus and Candida albicans

Abstract

In the current study, cephalexin and two beta-lactam antibiotics were combined with four distinct aldehydes: 3-hydroxybenzaldehyde, 4-dimethylaminobenzaldehyde, 4-methoxybenzaldehyde, and 4-bromobenzaldehyde, to synthesize Schiff bases. The reaction between the free amino group of the acylamino side chain and the aldehydes resulted in the formation of four Schiff bases within the medication. Comprehensive characterization and surface examination were performed on each Schiff base. The biological activity of the synthesized compounds against Bacillus Pumilus (Gram-positive bacteria) and Candida albicans (fungus) was evaluated using the agar diffusion disc method. The antibacterial screening tests revealed that the Schiff bases exhibited enhanced antibacterial activity against these microorganisms, indicating superior efficacy compared to the parent drugs. However, no significant inhibitory effect on the tested fungus was observed.

Keywords

• Schiff base; Cephalexin; Aldehydes; Bacillus Pumilus; Candida albicans.