Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy

Noriaki Miyanaga; Hideaki Takagi; Tomofumi Uto; Tomohiro Fukaya; Junta Nasu; Takehito Fukui; Yotaro Nishikawa; Tim Sparwasser; Narantsog Choijookhuu; Yoshitaka Hishikawa; Takeshi Nakamura; Tetsuya Tono; Katsuaki Sato

doi:10.1038/s42003-020-01466-3

Communications Biology (Dec 2020)

Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy

Noriaki Miyanaga,
Hideaki Takagi,
Tomofumi Uto,
Tomohiro Fukaya,
Junta Nasu,
Takehito Fukui,
Yotaro Nishikawa,
Tim Sparwasser,
Narantsog Choijookhuu,
Yoshitaka Hishikawa,
Takeshi Nakamura,
Tetsuya Tono,
Katsuaki Sato

Affiliations

Noriaki Miyanaga: Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki
Hideaki Takagi: Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki
Tomofumi Uto: Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki
Tomohiro Fukaya: Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki
Junta Nasu: Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki
Takehito Fukui: Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki
Yotaro Nishikawa: Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki
Tim Sparwasser: Department of Medical Microbiology and Hygiene, University Medical Center, Johannes Gutenberg University
Narantsog Choijookhuu: Division of Histochemistry and Cell Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki
Yoshitaka Hishikawa: Division of Histochemistry and Cell Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki
Takeshi Nakamura: Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, University of Miyazaki
Tetsuya Tono: Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, University of Miyazaki
Katsuaki Sato: Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki

DOI: https://doi.org/10.1038/s42003-020-01466-3
Journal volume & issue: Vol. 3, no. 1
pp. 1 – 12

Abstract

Read online

Noriaki Miyanaga and Hideaki Takagi et al. identify an essential role for migratory dendritic cells in mediating immunotherapy treatment against allergies in mice. They show that submandibular lymph node dendritic cells induce regulatory T cells, and their absence abrogates the effectiveness of immunotherapy treatment.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal