A rare case of acute myeloid leukemia with t(12;19)(q13;q13)

Alain Chebly; Fady Gh Haddad; Josiane Bassil; Tony Yammine; Rima Korban; Warde Semaan; Fady El Karak; Hampig Raphael Kourie; Chantal Farra

Leukemia Research Reports (Jan 2020)

A rare case of acute myeloid leukemia with t(12;19)(q13;q13)

Alain Chebly,
Fady Gh Haddad,
Josiane Bassil,
Tony Yammine,
Rima Korban,
Warde Semaan,
Fady El Karak,
Hampig Raphael Kourie,
Chantal Farra

Affiliations

Alain Chebly: Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Fady Gh Haddad: Department of Hematology and Oncology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Josiane Bassil: Department of Hematology and Oncology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Tony Yammine: Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Rima Korban: Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Warde Semaan: Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Fady El Karak: Department of Hematology and Oncology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Hampig Raphael Kourie: Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon; Department of Hematology and Oncology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Chantal Farra: Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon; Department of Genetics, Hotel Dieu de France Medical Center, Beirut, Lebanon; Corresponding author at: Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Damascus street, B.P. 17-5208, Mar Mikhaël, Beirut, 1104 2020 Beirut, Lebanon.

Journal volume & issue: Vol. 14
p. 100216

Abstract

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Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities.We herein, report a rare balanced translocation t(12;19)(q13;q13) in a 66-year old M5-AML patient identified by Conventional cytogenetic analysis and confirmed by SNP array. We suggest that t(12;19) as a sole chromosomal abnormality could be associated with a poor prognosis. Further studies are needed to understand the molecular basis of this translocation in AML.

Published in Leukemia Research Reports

ISSN: 2213-0489 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/leukemia-research-reports/

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