Nature Communications (Jun 2016)
Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics
- Eloy F. Robles,
- Maria Mena-Varas,
- Laura Barrio,
- Sara V. Merino-Cortes,
- Péter Balogh,
- Ming-Qing Du,
- Takashi Akasaka,
- Anton Parker,
- Sergio Roa,
- Carlos Panizo,
- Idoia Martin-Guerrero,
- Reiner Siebert,
- Victor Segura,
- Xabier Agirre,
- Laura Macri-Pellizeri,
- Beatriz Aldaz,
- Amaia Vilas-Zornoza,
- Shaowei Zhang,
- Sarah Moody,
- Maria Jose Calasanz,
- Thomas Tousseyn,
- Cyril Broccardo,
- Pierre Brousset,
- Elena Campos-Sanchez,
- Cesar Cobaleda,
- Isidro Sanchez-Garcia,
- Jose Luis Fernandez-Luna,
- Ricardo Garcia-Muñoz,
- Esther Pena,
- Beatriz Bellosillo,
- Antonio Salar,
- Maria Joao Baptista,
- Jesús Maria Hernandez-Rivas,
- Marcos Gonzalez,
- Maria Jose Terol,
- Joan Climent,
- Antonio Ferrandez,
- Xavier Sagaert,
- Ari M. Melnick,
- Felipe Prosper,
- David G. Oscier,
- Yolanda R. Carrasco,
- Martin J. S. Dyer,
- Jose A. Martinez-Climent
Affiliations
- Eloy F. Robles
- Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra
- Maria Mena-Varas
- Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra
- Laura Barrio
- Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC
- Sara V. Merino-Cortes
- Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC
- Péter Balogh
- Department of Immunology and Biotechnology, Szentágothai Research Center, University of Pécs
- Ming-Qing Du
- Division of Molecular Histopathology, Department of Pathology, Cambridge University
- Takashi Akasaka
- Department of Cancer Studies and Molecular Medicine, MRC Toxicology Unit and Ernest and Helen Scott Haematological Research Institute, University of Leicester
- Anton Parker
- Department of Haematology, Royal Bournemouth Hospital
- Sergio Roa
- Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra
- Carlos Panizo
- Department of Hematology, Clinica Universidad de Navarra
- Idoia Martin-Guerrero
- Institute of Human Genetics, Christian-Albrechts-University Kiel & University Hospital Schleswig-Holstein, Campus Kiel
- Reiner Siebert
- Institute of Human Genetics, Christian-Albrechts-University Kiel & University Hospital Schleswig-Holstein, Campus Kiel
- Victor Segura
- Department of Genomics and Proteomics, Bio-informatic Unit, Center for Applied Medical Research CIMA, University of Navarra
- Xabier Agirre
- Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra
- Laura Macri-Pellizeri
- Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra
- Beatriz Aldaz
- Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra
- Amaia Vilas-Zornoza
- Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra
- Shaowei Zhang
- Division of Molecular Histopathology, Department of Pathology, Cambridge University
- Sarah Moody
- Division of Molecular Histopathology, Department of Pathology, Cambridge University
- Maria Jose Calasanz
- Department of Genetics, School of Medicine, University of Navarra
- Thomas Tousseyn
- Centre for Translation Cell and Tissue Research, KU Leuven
- Cyril Broccardo
- Department of Pathology, Institut Universitaire du Cancer de Toulouse-Oncopole
- Pierre Brousset
- Department of Pathology, Institut Universitaire du Cancer de Toulouse-Oncopole
- Elena Campos-Sanchez
- Centro de Biologia Molecular Severo Ochoa, CSIC/Universidad Autonoma
- Cesar Cobaleda
- Centro de Biologia Molecular Severo Ochoa, CSIC/Universidad Autonoma
- Isidro Sanchez-Garcia
- Experimental Therapeutics and Translational Oncology Program, Institute of Molecular and Cellular Biology of Cancer, CSIC/University of Salamanca
- Jose Luis Fernandez-Luna
- Molecular Genetics Unit, University Hospital Marques de Valdecilla and IFIMAV
- Ricardo Garcia-Muñoz
- Hematology Department, Hospital San Pedro
- Esther Pena
- Department of Hematology, Complejo Hospitalario de Navarra, Servicio Navarro de Salud
- Beatriz Bellosillo
- Department of Pathology, Cancer Research Program, Institut Municipal d’Investigacions Mèdiques (IMIM), Hospital del Mar
- Antonio Salar
- Department of Clinical Hematology, Cancer Research Program, Institut Municipal d’Investigacions Mèdiques (IMIM), Hospital del Mar
- Maria Joao Baptista
- Department of Hematology, ICO-Hospital Universitari Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute, Universitat Autònoma de Barcelona
- Jesús Maria Hernandez-Rivas
- Department of Hematology, IBSAL-University Hospital and IBMCC-CSIC, University of Salamanca
- Marcos Gonzalez
- Department of Hematology, IBSAL-University Hospital and IBMCC-CSIC, University of Salamanca
- Maria Jose Terol
- Department of Hematology, Hospital Clinico, INCLIVA Biomedical Research Institute, University of Valencia
- Joan Climent
- Department of Hematology, Hospital Clinico, INCLIVA Biomedical Research Institute, University of Valencia
- Antonio Ferrandez
- Department of Pathology, Hospital Clinico, University of Valencia
- Xavier Sagaert
- Centre for Translation Cell and Tissue Research, KU Leuven
- Ari M. Melnick
- Department of Medicine/Hematology-Oncology, Weill Cornell Medical College
- Felipe Prosper
- Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra
- David G. Oscier
- Department of Haematology, Royal Bournemouth Hospital
- Yolanda R. Carrasco
- Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC
- Martin J. S. Dyer
- Department of Cancer Studies and Molecular Medicine, MRC Toxicology Unit and Ernest and Helen Scott Haematological Research Institute, University of Leicester
- Jose A. Martinez-Climent
- Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra
- DOI
- https://doi.org/10.1038/ncomms11889
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
The homeobox NKX2 family of transcriptional factors has been shown to regulate fundamental developmental processes. Here, the authors show that NKX2-3 is a bona fideoncogenic driver in marginal-zone B-cell lymphoma and that it promotes lymphomagenesis by shaping lymphocyte dynamics and promoting BCR signalling.
