Nature Communications (Feb 2023)

Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 spike protein

  • Christopher Cyrus Kuhn,
  • Nirakar Basnet,
  • Satish Bodakuntla,
  • Pelayo Alvarez-Brecht,
  • Scott Nichols,
  • Antonio Martinez-Sanchez,
  • Lorenzo Agostini,
  • Young-Min Soh,
  • Junichi Takagi,
  • Christian Biertümpfel,
  • Naoko Mizuno

DOI
https://doi.org/10.1038/s41467-023-36279-5
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 14

Abstract

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SARS-CoV-2 infection can cause coagulopathic events. Kuhn et al. show by cryo-ET how the Spike protein impacts platelet morphology by binding to the platelet surface, leading to micro-activation; and investigate integrin as possible point of contact.