Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling

Xinyan Zhu; Yu Qian; Xiaowan Li; Zhenmei Xu; Ruixue Xia; Na Wang; Jiale Liang; Han Yin; Anqi Zhang; Changyou Guo; Guangfu Wang; Yuanzheng He

doi:10.1038/s41467-022-33173-4

Nature Communications (Sep 2022)

Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling

Xinyan Zhu,
Yu Qian,
Xiaowan Li,
Zhenmei Xu,
Ruixue Xia,
Na Wang,
Jiale Liang,
Han Yin,
Anqi Zhang,
Changyou Guo,
Guangfu Wang,
Yuanzheng He

Affiliations

Xinyan Zhu: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, Harbin Institute of Technology
Yu Qian: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, Harbin Institute of Technology
Xiaowan Li: Laboratory of Neuroscience, HIT Center for Life Sciences, Harbin Institute of Technology
Zhenmei Xu: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, Harbin Institute of Technology
Ruixue Xia: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, Harbin Institute of Technology
Na Wang: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, Harbin Institute of Technology
Jiale Liang: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, Harbin Institute of Technology
Han Yin: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, Harbin Institute of Technology
Anqi Zhang: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Changyou Guo: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Guangfu Wang: Laboratory of Neuroscience, HIT Center for Life Sciences, Harbin Institute of Technology
Yuanzheng He: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, Harbin Institute of Technology

DOI: https://doi.org/10.1038/s41467-022-33173-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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aGPCRs play key roles in multiple physiological processes. Here the authors report cryo-EM structures of GPR110 in complexes with Gq, Gs, Gi, G12 and G13 protein to reveal a detailed mechanism of aGPCR activation via the tethered stalk peptide and principles of G-protein coupling and selectivity on GPR110.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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