PLoS ONE (Jan 2021)

External validation of the priapism impact profile in a Jamaican cohort of patients with sickle cell disease.

  • Belinda F Morrison,
  • Wendy Madden,
  • Monika Asnani,
  • Ayodeji Sotimehin,
  • Uzoma Anele,
  • Yuezhou Jing,
  • Bruce J Trock,
  • Arthur L Burnett

DOI
https://doi.org/10.1371/journal.pone.0258560
Journal volume & issue
Vol. 16, no. 10
p. e0258560

Abstract

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BackgroundPriapism impairs quality of life and has a predilection for males with sickle cell disease (SCD). The Priapism Impact Profile (PIP) is a novel 12-item instrument designed to measure general health-related impact of priapism. The aim of the study was to evaluate the validity and reliability of the PIP in a Jamaican cohort of SCD patients experiencing priapism.MethodsOne hundred SCD patients with a history of priapism were recruited from a sickle cell clinic in Kingston, Jamaica and administered the PIP questionnaire. Patients rated each item of the PIP for clarity and importance. Statistical testing was employed to evaluate the psychometric performance of the PIP. Content validation was assessed based on patient descriptive rating of the items based on clarity, and importance and criterion-oriented validity were assessed by evaluating the PIP's ability to distinguish between patient subgroups. Test-retest repeatability was assessed in 20 of the 100 patients.ResultsPatients were stratified into active (54) and remission (46) priapism groups based on their experience of priapism within the past year. Patients in the active priapism group were younger (p = 0.011), had a shorter duration of disease (p = 0.023), and had more frequent priapism episodes (p = 0.036) than the remission group. PIP questionnaire scores differed significantly with respect to priapism activity (p ConclusionThe PIP questionnaire was successfully validated in a Jamaican cohort of SCD patients and adequately discriminated patients with active priapism from those in remission. The instrument may be utilized in routine clinical management of patients with SCD-associated priapism. Further clinical investigations are warranted in other populations.