A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

Alexander L. Antaris; Hao Chen; Shuo Diao; Zhuoran Ma; Zhe Zhang; Shoujun Zhu; Joy Wang; Alexander X. Lozano; Quli Fan; Leila Chew; Mark Zhu; Kai Cheng; Xuechuan Hong; Hongjie Dai; Zhen Cheng

doi:10.1038/ncomms15269

Nature Communications (May 2017)

A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

Alexander L. Antaris,
Hao Chen,
Shuo Diao,
Zhuoran Ma,
Zhe Zhang,
Shoujun Zhu,
Joy Wang,
Alexander X. Lozano,
Quli Fan,
Leila Chew,
Mark Zhu,
Kai Cheng,
Xuechuan Hong,
Hongjie Dai,
Zhen Cheng

Affiliations

Alexander L. Antaris: Department of Chemistry, Stanford University
Hao Chen: State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Wuhan University School of Pharmaceutical Sciences
Shuo Diao: Department of Chemistry, Stanford University
Zhuoran Ma: Department of Chemistry, Stanford University
Zhe Zhang: and Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University
Shoujun Zhu: Department of Chemistry, Stanford University
Joy Wang: Department of Chemistry, Stanford University
Alexander X. Lozano: Department of Chemistry, Stanford University
Quli Fan: and Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University
Leila Chew: Department of Chemistry, Stanford University
Mark Zhu: and Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University
Kai Cheng: and Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University
Xuechuan Hong: State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Wuhan University School of Pharmaceutical Sciences
Hongjie Dai: Department of Chemistry, Stanford University
Zhen Cheng: and Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University

DOI: https://doi.org/10.1038/ncomms15269
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Near-infrared (NIR) fluorescence imaging >1,000 nm allows deep tissue imaging, but available organic dyes display poor brightness and temporal resolution. Here, the authors synthesize a NIR dye that, upon binding serum proteins, exhibits a 110-fold increase in intensity, giving an 11% quantum yield.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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