DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1

Peijun Han; Wei Ye; Hongwei Ma; Yangchao Dong; Xin Lv; He Liu; Linfeng Cheng; Liang Zhang; Sumin Li; Yingfeng Lei; Fanglin Zhang

International Journal of Medical Microbiology (Jun 2025)

DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1

Peijun Han,
Wei Ye,
Hongwei Ma,
Yangchao Dong,
Xin Lv,
He Liu,
Linfeng Cheng,
Liang Zhang,
Sumin Li,
Yingfeng Lei,
Fanglin Zhang

Affiliations

Peijun Han: Department of Aerospace Hygiene, School of Aerospace Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, China
Wei Ye: Department of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, China
Hongwei Ma: Department of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, China
Yangchao Dong: Department of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, China
Xin Lv: Department of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, China
He Liu: Department of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, China
Linfeng Cheng: Department of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, China
Liang Zhang: Department of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, China
Sumin Li: Department of Aerospace Hygiene, School of Aerospace Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, China
Yingfeng Lei: Department of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, China
Fanglin Zhang: Department of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, China; Corresponding author.

Journal volume & issue: Vol. 319
p. 151654

Abstract

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Dengue virus (DENV) is one of the major arboviruses that pose a serious threat to global human health. However, there is currently no specific antiviral drug available for the treatment of DENV infection. DDX17, a member of the DExD/H-box helicase family, has been implicated in the replication processes of various viruses. Our research group discovered that during the early stages of dengue virus replication, DDX17 promotes viral replication and suppresses the activity of the IFN promoter. Furthermore, DDX17 binds to viral dsRNA and interacts with G3BP1, a component of stress granules (SGs), to inhibit SG formation, thereby enhancing viral replication. By elucidating the role of DDX17 in the early stages of dengue virus replication, our findings provide valuable insights into host-pathogen interactions during DENV infection, offering potential therapeutic perspectives.

Published in International Journal of Medical Microbiology

ISSN: 1438-4221 (Print); 1618-0607 (Online)
Publisher: Elsevier
Country of publisher: Germany
LCC subjects: Science: Microbiology; Medicine: Other systems of medicine
Website: https://www.journals.elsevier.com/international-journal-of-medical-microbiology

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