Combined antihypertensive treatment in hypertensive patients and type 2 diabetes mellitus

Abstract

Aim. To investigate antihypertensive efficacy, effects on endothelial, diastolic function of the left ventricule and metabolism of combination of ACE inhibitor quinapril (accupro) with diuretic indapamide SR in patients with hypertension of the second-third degree and type 2 diabetes mellitus (DM) and free of DM. Material and methods. Outpatient treatment was given to 60 patients with AH (mean age 55.3 ± 9.6 years) in combination with mild or moderate DM (group 1) and free of DM (group 2). The patients were observed for 12 weeks. Clinical and biochemical blood tests, ECG, echo-CG, measurements of blood pressure were made in all the patients. Results. Quinapril course (mean dose 23.3 ± 9.8 mg/day) in combination with indapamide (1.5 mg/day) produced a complete hypotensive effect in group 1 (23 patients,76.7%), in group 2 - 25 (83.3%). DM patients demonstrated reduction of fasting and postprandial glycemia and cholesterol, time of isovolumic relaxation reduced in group 1 by 9.1%, in group 2 by 19.8% (p < 0.01). Left ventricular diastolic function improved, endothelium-dependent vasodilation in diabetics rose by 40%, non-endothelium-dependent - by 21.8%, in hypertensive patients free of DM - by 51.9 and 43.2%, respectively. Conclusion. Combination of quinapril with indapamide produces a significant antihypertensive effect in patients with AH of degree II-III associated with type 2 DM, improves carbohydrate and lipid metabolism, left ventricular diastolic function.

Keywords

• arterial hypertension
• diabetes mellitus
• quinapril
• indapamide