Frontiers in Cardiovascular Medicine (May 2022)
Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors
- Oxana Rotar,
- Maria Boyarinova,
- Ekaterina Moguchaya,
- Kristina Tolkunova,
- Nikita Kolosov,
- Nikita Kolosov,
- Nikita Kolosov,
- Valeriia Rezapova,
- Valeriia Rezapova,
- Valeriia Rezapova,
- Olga Freylikhman,
- Dmitrii Usoltsev,
- Dmitrii Usoltsev,
- Dmitrii Usoltsev,
- Olesya Melnik,
- Alexey Sergushichev,
- Vladislav Solntsev,
- Anna Kostareva,
- Elena Dubinina,
- Elena Dubinina,
- Trudy Voortman,
- Trudy Voortman,
- Christine Stevens,
- Mark J. Daly,
- Mark J. Daly,
- Mark J. Daly,
- Alexandra Konradi,
- Alexandra Konradi,
- Evgeny Shlyakhto,
- Mykyta Artomov,
- Mykyta Artomov,
- Mykyta Artomov,
- Mykyta Artomov,
- Mykyta Artomov
Affiliations
- Oxana Rotar
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Maria Boyarinova
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Ekaterina Moguchaya
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Kristina Tolkunova
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Nikita Kolosov
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Nikita Kolosov
- ITMO University, Saint Petersburg, Russia
- Nikita Kolosov
- Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States
- Valeriia Rezapova
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Valeriia Rezapova
- ITMO University, Saint Petersburg, Russia
- Valeriia Rezapova
- Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States
- Olga Freylikhman
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Dmitrii Usoltsev
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Dmitrii Usoltsev
- ITMO University, Saint Petersburg, Russia
- Dmitrii Usoltsev
- Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States
- Olesya Melnik
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Alexey Sergushichev
- ITMO University, Saint Petersburg, Russia
- Vladislav Solntsev
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Anna Kostareva
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Elena Dubinina
- Herzen State Pedagogical University of Russia, Saint Petersburg, Russia
- Elena Dubinina
- V.M. Bekhterev National Research Medical Center for Psychiatry and Neurology, Saint Petersburg, Russia
- Trudy Voortman
- Erasmus Medical Center, Rotterdam, Netherlands
- Trudy Voortman
- Division of Nutrition and Health, Wageningen University, Wageningen, Netherlands
- Christine Stevens
- Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States
- Mark J. Daly
- Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States
- Mark J. Daly
- Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States
- Mark J. Daly
- Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland
- Alexandra Konradi
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Alexandra Konradi
- ITMO University, Saint Petersburg, Russia
- Evgeny Shlyakhto
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Mykyta Artomov
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Mykyta Artomov
- ITMO University, Saint Petersburg, Russia
- Mykyta Artomov
- Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States
- Mykyta Artomov
- Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States
- Mykyta Artomov
- Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland
- DOI
- https://doi.org/10.3389/fcvm.2022.843439
- Journal volume & issue
-
Vol. 9
Abstract
Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.
Keywords
