Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice

Hanxiao Liu; Xinxing Wang; Lu Chen; Liang Chen; Stella E. Tsirka; Shaoyu Ge; Qiaojie Xiong

doi:10.1038/s41467-021-24915-x

Nature Communications (Jul 2021)

Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice

Hanxiao Liu,
Xinxing Wang,
Lu Chen,
Liang Chen,
Stella E. Tsirka,
Shaoyu Ge,
Qiaojie Xiong

Affiliations

Hanxiao Liu: Department of Neurobiology and Behavior, Stony Brook University
Xinxing Wang: Department of Neurobiology and Behavior, Stony Brook University
Lu Chen: Department of Neurobiology and Behavior, Stony Brook University
Liang Chen: Department of Neurobiology and Behavior, Stony Brook University
Stella E. Tsirka: Department of Pharmacological Sciences, Stony Brook University
Shaoyu Ge: Department of Neurobiology and Behavior, Stony Brook University
Qiaojie Xiong: Department of Neurobiology and Behavior, Stony Brook University

DOI: https://doi.org/10.1038/s41467-021-24915-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Here, the authors show that microglia depletion results in unstable wakefulness and altered levels of ceramide, influencing microglia in the mouse thalamic reticular nucleus (TRN). Stable wakefulness can be restored by activation of the TRN or inhibition of ceramide production in the mouse brain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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