Einstein (São Paulo) (Sep 2011)

Analysis of the action of Himatanthus drasticus in progression of urethane-induced lung cancer in mice

  • Wendy Caroline de Souza Costa França,
  • Ana Cláudia Rodrigues Lopes Amaral de Souza,
  • José Antônio Cordeiro,
  • Patricia Maluf Cury

DOI
https://doi.org/10.1590/s1679-45082011ao2013
Journal volume & issue
Vol. 9, no. 3
pp. 350 – 353

Abstract

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ABSTRACT Objective: To evaluate the effect of janaguba in inhibiting the development of lung cancer in an experimental urethane-induced model. Methods: a total of 3mg/kg urethane was injected in 51 Balb-C mice aged 7-13 weeks of life. Janaguba was administered orally daily in two doses: 0.04 mL (Group 2, G2) and 0.06 mL (Group 3, G3), for 20 weeks. After this period, the mice were sacrificed and the number of lesions counted. Results: The mean weight of Group 2 was lower than that of Group 3, and that of Group 1 (Control, G1) (G1 = 35.533 g; G2 = 33.359 g; G3 = 37.125 g). The number of nodules did not differ between groups (mean G1 = G2 = G3 = 1; p = 0.88). Conclusion: Janaguba had an effect on the growth of mice, but had no influence on the progression of lung cancer in this model.

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