Scientific Reports (Feb 2024)

LDCT screening results among eligible and ineligible screening candidates in preventive health check-ups population: a real world study in West China

  • Ting Bao,
  • Bingqing Liu,
  • Ruicen Li,
  • Zhenzhen Li,
  • Guiyi Ji,
  • Youjuan Wang,
  • Hanwei Yang,
  • Weimin Li,
  • Wenxia Huang,
  • Yan Huang,
  • Huairong Tang

DOI
https://doi.org/10.1038/s41598-024-55475-x
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 9

Abstract

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Abstract To compare the LDCT screening results between eligible and ineligible screening candidates in preventive health check-ups population. Using a real-world LDCT screening results among people who took yearly health check-up in health management center of West China Hospital between 2006 and 2017. Objects were classified according to the China National Lung Cancer Screening Guideline with Low-dose Computed Tomography (2018 version) eligibility criteria. Descriptive analysis were performed between eligible and ineligible screening candidates. The proportion of ineligible screening candidates was 64.13% (10,259), and among them there were 4005 (39.04%) subjects with positive screenings, 80 cases had a surgical lung biopsy. Pathology results from lung biopsy revealed 154 cancers (true-positive) and 26 benign results (false-positive), the surgical false-positive biopsy rate was 4.17%, and ineligible group (7.69%) was higher than eligible group (2.47%), P < 0.05. Further, in ineligible screening candidates, the proportion of current smokers was higher among males compared to females (53.85% vs. 4.88%, P < 0.05). Of the 69 lung cancer patients detected in ineligible screening candidates, lung adenocarcinoma accounts for a high proportion of lung cancers both in male (75.00%) and female (85.00%). The proportion of ineligible screening candidates and the surgical false-positive biopsy rate in ineligible candidates were both high in health check-ups population.

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