A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

T. Azad; H. J. Janse van Rensburg; E. D. Lightbody; B. Neveu; A. Champagne; A. Ghaffari; V. R. Kay; Y. Hao; H. Shen; B. Yeung; B. A. Croy; K. L. Guan; F. Pouliot; J. Zhang; C. J. B. Nicol; X. Yang

doi:10.1038/s41467-018-03278-w

Nature Communications (Mar 2018)

A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

T. Azad,
H. J. Janse van Rensburg,
E. D. Lightbody,
B. Neveu,
A. Champagne,
A. Ghaffari,
V. R. Kay,
Y. Hao,
H. Shen,
B. Yeung,
B. A. Croy,
K. L. Guan,
F. Pouliot,
J. Zhang,
C. J. B. Nicol,
X. Yang

Affiliations

T. Azad: Department of Pathology and Molecular Medicine, Queen’s University
H. J. Janse van Rensburg: Department of Pathology and Molecular Medicine, Queen’s University
E. D. Lightbody: Department of Pathology and Molecular Medicine, Queen’s University
B. Neveu: Department of Surgery (Urology), CHU de Québec-Université Laval Research Center, Laval University
A. Champagne: Department of Surgery (Urology), CHU de Québec-Université Laval Research Center, Laval University
A. Ghaffari: Department of Pathology and Molecular Medicine, Queen’s University
V. R. Kay: Department of Biomedical and Molecular Sciences, Queen’s University
Y. Hao: Department of Pathology and Molecular Medicine, Queen’s University
H. Shen: Department of Cancer Genetics and Genomics, Roswell Park Cancer Institute
B. Yeung: Department of Pathology and Molecular Medicine, Queen’s University
B. A. Croy: Department of Biomedical and Molecular Sciences, Queen’s University
K. L. Guan: Department of Pharmacology, University of California at San Diego
F. Pouliot: Department of Surgery (Urology), CHU de Québec-Université Laval Research Center, Laval University
J. Zhang: Department of Cancer Genetics and Genomics, Roswell Park Cancer Institute
C. J. B. Nicol: Department of Pathology and Molecular Medicine, Queen’s University
X. Yang: Department of Pathology and Molecular Medicine, Queen’s University

DOI: https://doi.org/10.1038/s41467-018-03278-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

The Hippo pathway is a major orchestrator of organ development and homeostasis. Here Azad and colleagues develop a biosensor to monitor the activity of the Hippo pathway component LATS and identify VEGF signalling as an upstream regulator of LATS, supporting a role for Hippo signalling during angiogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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