Nature Communications (Oct 2021)

Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold

  • Nina Schweizer,
  • Laurence Haren,
  • Ilaria Dutto,
  • Ricardo Viais,
  • Cristina Lacasa,
  • Andreas Merdes,
  • Jens Lüders

DOI
https://doi.org/10.1038/s41467-021-26252-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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The γ-tubulin ring complex (γTuRC) nucleates microtubules at the centrosome, but how this function is related to γTuRC subcentrosomal distribution is unclear. Here the authors show that γTuRC in the centriole lumen has a nucleation-independent role in centriole integrity and cilium assembly.