An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides

Sean M. Armour; Jarrett R. Remsberg; Manashree Damle; Simone Sidoli; Wesley Y. Ho; Zhenghui Li; Benjamin A. Garcia; Mitchell A. Lazar

doi:10.1038/s41467-017-00772-5

Nature Communications (Sep 2017)

An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides

Sean M. Armour,
Jarrett R. Remsberg,
Manashree Damle,
Simone Sidoli,
Wesley Y. Ho,
Zhenghui Li,
Benjamin A. Garcia,
Mitchell A. Lazar

Affiliations

Sean M. Armour: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Jarrett R. Remsberg: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Manashree Damle: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Simone Sidoli: Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania
Wesley Y. Ho: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Zhenghui Li: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Benjamin A. Garcia: Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania
Mitchell A. Lazar: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania

DOI: https://doi.org/10.1038/s41467-017-00772-5
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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HDAC3 is a critical mediator of hepatic lipid metabolism and its loss leads to fatty liver. Here, the authors characterize the liver HDAC3 interactome in vivo, provide evidence that HDAC3 interacts with PROX1, and show that HDAC3 and PROX1 control expression of genes regulating lipid homeostasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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