Arquivos de Neuro-Psiquiatria (May 2015)

Clinical predictors of cognitive impairment and psychiatric complications in Parkinson’s disease

  • Lidiane S. Campos,
  • Rachel P. Guimarães,
  • Luiza G. Piovesana,
  • Paula C. de Azevedo,
  • Leonilda M. B. Santos,
  • Anelyssa D’Abreu

DOI
https://doi.org/10.1590/0004-282X20150016
Journal volume & issue
Vol. 73, no. 5
pp. 390 – 395

Abstract

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Objective To estimate the clinical and demographics aspects that may contribute to cognitive impairment and psychiatric symptoms in Parkinson’s disease (PD). Method All patients answered a structured standardized clinical questionnaire. Two movement disorders specialists performed the following scale: Unified Parkinson’s disease rating score (UPDRS), the modified Hoehn and Yahr staging, Schwab and England Scale, SCOPA cognition (SCOPA-COG), SCOPA-Psychiatric complications (SCOPA-PC) and Non-Motor Symptoms Scale (NMSS). We built a generalized linear model to assess predictors for the SCOPA-COG and SCOPA-PC scores. Results Almost 37% of our patients were demented as per SCOPA-COG scores. Level of education and the UPDRS-Subscale III were predictors of cognitive impairment. Higher scores in domain 3 of NMSS and male gender were associated with psychiatric complications as assessed per the SCOPA-PC. Conclusion Level of education and disease severity are predictors of dementia in PD. Psychiatric complications are more commonly observed in men.

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