Revista Espanola de Enfermedades Digestivas (Jul 2007)
Prevalencia de la infección por Helicobacter pylori en el linfoma MALT gástrico: una revisión sistemática Prevalence of Helicobacter pylori infection in gastric MALT lymphoma: a systematic review
Abstract
Objetivo: realizar una revisión sistemática de los estudios que evalúan la prevalencia de H. pylori en los pacientes con linfoma MALT, así como analizar los factores de los que depende. Métodos: se efectuó una búsqueda bibliográfica en Pubmed seleccionando aquellos artículos en los que se estudiaba la prevalencia de H. pylori en pacientes con linfoma MALT. Resultados: se identificaron 38 estudios, incluyendo un total de 1.844 pacientes. La prevalencia media global de infección por H. pylori fue del 79%. En pacientes en los que se utilizaron 2 o más métodos para el diagnóstico de H. pylori la prevalencia fue del 85%, frente al 77% cuando se empleó un método diagnóstico (p Objective: to perform a systematic review of studies evaluating H. pylori prevalence in patients with MALT lymphoma, and to analyze predictive factors of response. Methods: a literature search in Pubmed was performed of papers studying H. pylori prevalence in patients with MALT lymphoma. Results: 38 studies were identified including 1,844 patients. The average prevalence of H. pylori infection was 79%. In patients diagnosed with H. pylori infection using 2 or more methods prevalence was 85%, whereas it was 77% when only one diagnostic method was used (p < 0.0001). H. pylori prevalence in patients diagnosed by histology was 75%, whereas it was 85% when serology was used (p < 0.0001). H. pylori prevalence in high-grade lymphomas was 60%, and 79% in low-grade lymphomas (p < 0.0001). H. pylori infection was detected in 74% of lymphomas confined to the submucosa, but only in 44% of those reaching deeper beyond the submucosa (p < 0.0001). Conclusions: H. pylori prevalence in patients with MALT lymphoma is variable, and seems to depend, at least partly, on the number and type of diagnostic methods used, histologic grade, and deep tumor invasion. If appropriate diagnostic methods are used, and if only low-grade lymphomas are considered, H. pylori prevalence is high, nearly 90%, which reinforces the role of these bacteria in gastric MALT lymphoma.
