Nature Communications (May 2020)
Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins
- Fengming Liu,
- Shen Dai,
- Dechun Feng,
- Zhongnan Qin,
- Xiao Peng,
- Siva S. V. P. Sakamuri,
- Mi Ren,
- Li Huang,
- Min Cheng,
- Kabir E. Mohammad,
- Ping Qu,
- Yong Chen,
- Chunling Zhao,
- Faliang Zhu,
- Shujian Liang,
- Bertal H. Aktas,
- Xiaofeng Yang,
- Hong Wang,
- Prasad V. G. Katakam,
- David W. Busija,
- Tracy Fischer,
- Prasun K. Datta,
- Jay Rappaport,
- Bin Gao,
- Xuebin Qin
Affiliations
- Fengming Liu
- Division of Comparative Pathology, Tulane National Primate Research Center
- Shen Dai
- Department of Neuroscience, Temple University Lewis Katz School of Medicine
- Dechun Feng
- Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- Zhongnan Qin
- Division of Comparative Pathology, Tulane National Primate Research Center
- Xiao Peng
- Department of Neuroscience, Temple University Lewis Katz School of Medicine
- Siva S. V. P. Sakamuri
- Department of Pharmacology, Tulane University School of Medicine
- Mi Ren
- Division of Comparative Pathology, Tulane National Primate Research Center
- Li Huang
- Department of Neuroscience, Temple University Lewis Katz School of Medicine
- Min Cheng
- Department of Neuroscience, Temple University Lewis Katz School of Medicine
- Kabir E. Mohammad
- Division of Comparative Pathology, Tulane National Primate Research Center
- Ping Qu
- Department of Neuroscience, Temple University Lewis Katz School of Medicine
- Yong Chen
- Department of Neuroscience, Temple University Lewis Katz School of Medicine
- Chunling Zhao
- Department of Neuroscience, Temple University Lewis Katz School of Medicine
- Faliang Zhu
- Department of Neuroscience, Temple University Lewis Katz School of Medicine
- Shujian Liang
- Department of Neuroscience, Temple University Lewis Katz School of Medicine
- Bertal H. Aktas
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Xiaofeng Yang
- Center for Metabolic Disease Research and Cardiovascular Research, Temple University Lewis Katz School of Medicine
- Hong Wang
- Center for Metabolic Disease Research and Cardiovascular Research, Temple University Lewis Katz School of Medicine
- Prasad V. G. Katakam
- Department of Pharmacology, Tulane University School of Medicine
- David W. Busija
- Department of Pharmacology, Tulane University School of Medicine
- Tracy Fischer
- Division of Comparative Pathology, Tulane National Primate Research Center
- Prasun K. Datta
- Department of Neuroscience, Temple University Lewis Katz School of Medicine
- Jay Rappaport
- Division of Comparative Pathology, Tulane National Primate Research Center
- Bin Gao
- Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- Xuebin Qin
- Division of Comparative Pathology, Tulane National Primate Research Center
- DOI
- https://doi.org/10.1038/s41467-020-16158-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Renal macrophages (RMs) can be of bone marrow or embryonic origin, but their abundance, fate and metabolic profiles in physiological and pathogenic settings are still unclear. Here the authors show, by characterizing these two RMs in multiple transgenic mouse lines, that they exhibit distinct dynamics, homeostasis, immune activity, and metabolic properties.
