2, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies

Afreen Md; Venkanna Muripiti; Shireesha Manturthi; Amarnath Velidandi

Results in Chemistry (Jan 2024)

2, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies

Afreen Md,
Venkanna Muripiti,
Shireesha Manturthi,
Amarnath Velidandi

Affiliations

Afreen Md: Department of Chemistry, Chaitanya Deemed to Be University, Hanamakonda, 506001, Telangana State, India
Venkanna Muripiti: Department of education, Central university of Kerala, Kasaragod, Kerala, India
Shireesha Manturthi: Cellular and Molecular Medicine, University of Ottawa, RGN 2501, 451 Smyth Road, Ontario, Ottawa, ON K1H 8M5, Canada
Amarnath Velidandi: Department of Chemistry, Chaitanya Deemed to Be University, Hanamakonda, 506001, Telangana State, India; Corresponding author.

Journal volume & issue: Vol. 7
p. 101425

Abstract

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Existing of a cell depends on the pyrimidine moiety; it controls many functions which lead to alter the action of organs. Herein, we demonstrate the synthesis, biological evolution of newer pyrimidins. Titled compounds are formed with good yields, there In-silico studies indicating good drug likeness, drug score. The In- vitro cell viability studies using lipofectamine 2000 as reference, reveals that IC50 values for pyrimidine-II, III against GL261, pyrimidine- VIII,IX against 4 T1 Celline shows prominent results.

Published in Results in Chemistry

ISSN: 2211-7156 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: https://www.journals.elsevier.com/results-in-chemistry/

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