Nature Communications (Oct 2017)

NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury

  • Zhikai Xiahou,
  • Xiangli Wang,
  • Juan Shen,
  • Xiaoxiao Zhu,
  • Feng Xu,
  • Rong Hu,
  • Deyin Guo,
  • Henan Li,
  • Yong Tian,
  • Yingfang Liu,
  • Huanhuan Liang

DOI
https://doi.org/10.1038/s41467-017-00930-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 and NF-κB pathways.