TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis

José A. Aguilar-Briseño; Vinit Upasani; Bram M. ter Ellen; Jill Moser; Mindaugas Pauzuolis; Mariana Ruiz-Silva; Sothy Heng; Denis Laurent; Rithy Choeung; Philippe Dussart; Tineke Cantaert; Jolanda M. Smit; Izabela A. Rodenhuis-Zybert

doi:10.1038/s41467-020-16849-7

Nature Communications (Jun 2020)

TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis

José A. Aguilar-Briseño,
Vinit Upasani,
Bram M. ter Ellen,
Jill Moser,
Mindaugas Pauzuolis,
Mariana Ruiz-Silva,
Sothy Heng,
Denis Laurent,
Rithy Choeung,
Philippe Dussart,
Tineke Cantaert,
Jolanda M. Smit,
Izabela A. Rodenhuis-Zybert

Affiliations

José A. Aguilar-Briseño: Department of Medical Microbiology and Infection Prevention, University of Groningen and University Medical Center Groningen
Vinit Upasani: Department of Medical Microbiology and Infection Prevention, University of Groningen and University Medical Center Groningen
Bram M. ter Ellen: Department of Medical Microbiology and Infection Prevention, University of Groningen and University Medical Center Groningen
Jill Moser: Departments of Critical Care, Pathology & Medical Biology, Medical Biology section, University Medical Center Groningen, University of Groningen
Mindaugas Pauzuolis: Department of Medical Microbiology and Infection Prevention, University of Groningen and University Medical Center Groningen
Mariana Ruiz-Silva: Department of Medical Microbiology and Infection Prevention, University of Groningen and University Medical Center Groningen
Sothy Heng: Kantha Bopha Hospital
Denis Laurent: Kantha Bopha Hospital
Rithy Choeung: Virology Unit, Institut Pasteur du Cambodge, International Network of Pasteur Institutes
Philippe Dussart: Virology Unit, Institut Pasteur du Cambodge, International Network of Pasteur Institutes
Tineke Cantaert: Immunology Group, Institut Pasteur du Cambodge, International Network of Pasteur Institutes
Jolanda M. Smit: Department of Medical Microbiology and Infection Prevention, University of Groningen and University Medical Center Groningen
Izabela A. Rodenhuis-Zybert: Department of Medical Microbiology and Infection Prevention, University of Groningen and University Medical Center Groningen

DOI: https://doi.org/10.1038/s41467-020-16849-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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The mechanisms underlying immunpathologies in dengue virus (DENV) infection are incompletely understood. Here, authors show that TLR2 recognizes DENV particles inducing cytokine expression and activating vascular endothelium cells in vitro, and that TLR2 expression on monocytes correlates with disease severity in patients.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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