Nature Communications (Feb 2017)

Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma

  • Aviram Mizrachi,
  • Yosi Shamay,
  • Janki Shah,
  • Samuel Brook,
  • Joanne Soong,
  • Vinagolu K. Rajasekhar,
  • John L. Humm,
  • John H. Healey,
  • Simon N. Powell,
  • José Baselga,
  • Daniel A. Heller,
  • Adriana Haimovitz-Friedman,
  • Maurizio Scaltriti

DOI
https://doi.org/10.1038/ncomms14292
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Head and neck squamous cell carcinomas (HNSCC) often harbourPIK3CAmutations but PI3Kα inhibitors can cause some side effects. Here, the authors develop P-selectin targeted nanoparticles to enhance tumour-specific delivery of a PI3Kα inhibitor to HNSCC PDX and orthotopic xenograft models.