Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries

Yunpeng Ji; Pengfei Li; Yueqi Jia; Xiaohua Wang; Qinyue Zheng; Maikel P. Peppelenbosch; Zhongren Ma; Qiuwei Pan

One Health (Dec 2021)

Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries

Yunpeng Ji,
Pengfei Li,
Yueqi Jia,
Xiaohua Wang,
Qinyue Zheng,
Maikel P. Peppelenbosch,
Zhongren Ma,
Qiuwei Pan

Affiliations

Yunpeng Ji: Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, China; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands; Department of Genetics, Inner Mongolian Maternal and Child Care Hospital, Inner Mongolian, China
Pengfei Li: Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands
Yueqi Jia: Department of Genetics, Inner Mongolian Maternal and Child Care Hospital, Inner Mongolian, China
Xiaohua Wang: Department of Genetics, Inner Mongolian Maternal and Child Care Hospital, Inner Mongolian, China
Qinyue Zheng: School of Management, Shandong Key Laboratory of Social Supernetwork Computation and Decision Simulation, Shandong University, Jinan, China
Maikel P. Peppelenbosch: Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands
Zhongren Ma: Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, China; Corresponding authors at: Biomedical Research Center, Northwest Minzu University, No. 1, Xibei Xincun, Lanzhou 730030, China.
Qiuwei Pan: Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, China; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands; Corresponding authors at: Biomedical Research Center, Northwest Minzu University, No. 1, Xibei Xincun, Lanzhou 730030, China.

Journal volume & issue: Vol. 13
p. 100350

Abstract

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Hepatitis E virus (HEV) is an emerging zoonotic pathogen posing global health burden, and the concerns in Europe are tremendously growing. Pigs serve as a main reservoir, contributing to pork-related foodborne transmission. In this study, we aim to specifically simulate this foodborne transmission route and to assess potential interventions. We firstly established a dose-response relationship between the risk of transmission to human and the amount of ingested viruses. We further estimated the incidence of HEV infection specifically attributed to pork-related foodborne transmission in four representative European countries. Finally, we demonstrated a proof-of-concept of mitigating HEV transmission by implementing vaccination in human and pig populations. Our modeling approach bears essential implications for better understanding the transmission of pork-related foodborne HEV and for developing mitigation strategies.

Published in One Health

ISSN: 2352-7714 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General)
Website: https://www.journals.elsevier.com/one-health

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