Nano-curcumin effects on nicotine dependence, depression, anxiety and metabolic parameters in smokers: A randomized double-blind clinical study
Peyman Mamsharifi,
Bahareh Farokhi,
Raha Hajipoor-Taziani,
Fatemeh Alemi,
Pooya Hazegh,
Shaghayegh Masoumzadeh,
Leila Jafari,
Amir Ghaderi,
Somayeh Ghadami Dehkohneh
Affiliations
Peyman Mamsharifi
Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran; Department of Psychology, Allameh Tabataba'i University, Tehran, Iran
Bahareh Farokhi
Department of Clinical Psychology, Allameh Tabataba'i University, Tehran, Iran
Raha Hajipoor-Taziani
Department of General Psychology, Islamic Azad University of Qeshm Branch, Qeshm, Iran
Fatemeh Alemi
Department of Toxicology and Pharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Pooya Hazegh
Department of Psychiatry, Kashan University of Medical Sciences, Kashan, Iran
Shaghayegh Masoumzadeh
Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
Leila Jafari
Department of Addiction Studies, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Amir Ghaderi
Clinical Research Development Unit-Matini/Kargarnejad Hospital, Kashan University of Medical Sciences, Kashan, Iran; Department of Addiction Studies, School of Medical, Kashan University of Medical Sciences, Kashan, Iran; Corresponding author. Clinical Research Development Unit-Matini/Kargarnejad Hospital, Kashan University of Medical Sciences, Kashan, Iran.
Somayeh Ghadami Dehkohneh
Department of Pharmacy, Acharya BM ready college of Pharmacy, Rajive Gandhi University of Health Sciences, Banglore Karnataka, India; Corresponding author. Department of Pharmacy, Acharya BM ready college of Pharmacy, Rajive Gandhi University of Health Sciences, Banglore Karnataka, India.
Background: Smoking is clearly associated with metabolic profiles/abnormalities, psychological dysfunction, and symptoms of nicotine dependence. Nano-Curcumin (Nano-CUR) is a medicinal herb with antianxiety, antioxidant antidepressant‐like effects, and anti-inflammatory properties. This RCT aimed to determine the therapeutic effects of Nano-CUR in smokers on clinical symptoms and metabolic parameters. Methods: This trial was conducted on 70 participants with cigarette smoking. Smokers in two arms received soft gel capsules Nano-CUR 80 mg/daily for 3 months (n = 35) and placebo (n = 35), respectively. Primary outcomes (Nicotine dependence syndrome scale, depression, and anxiety beck score), and secondary outcomes (glycemic, lipid, stress oxidative, and inflammation profiles) were analyzed before and 3-months after the intervention in smokers. Results: Nano-CUR supplementation significantly decreased nitric oxide, malondialdehyde, and C-reactive protein levels (P 0.05). Conclusion: Nano-CUR intake may have favorable effects on C-reactive protein, malondialdehyde, and nitric oxide in subjects with cigarette smoking. More RCT are required to evaluate the effectiveness of Nano-CUR supplementations in smokers in order to reject or support these conclude.
