T LYMPHOCYTE SUBSETS STUDIED IN A PATIENT WITH TWO ASSOCIATED HEMATOLOGIC NEOPLASIAS – CHRONIC LYMPHOCYTIC LEUKEMIA B AND CHRONIC MYELOID LEUKEMIA

Abstract

Quantification of various cellular subpopulations facilitates the monitoring of hematological diseases, including chronic lymphocytic leukemia. Variations in the proportions of regulatory T cells in peripheral blood have been described in patients with immune changes such as allergies, autoimmune diseases and haematological diseases such as chronic lymphocytic leukemia. In this article, the T lymphocyte subsets have been studied using flow cytometry in a patient with two associated hematologic neoplasms. The simultaneous presence of two chronic hematopathies has been confirmed: chronic lymphocytic leukemia (CLL-B) and chronic myeloid leukemia (CML). Chronic lymphocytic leukemia is a frequent malignant hematopathy, a monoclonal expansion of B lymphocytes, while chronic myeloid leukemia is a rare subtype of chronic myeloid leukemia, and the association of the two subtypes is rarely reported in the literature. The following describes the case of a patient diagnosed with chronic lymphocytic leukemia B (LLC-B) who developed during the course of the disease, most likely secondary to the chemotherapy the second hematological neoplasia – chronic myeloid leukemia.

Keywords

• chronic lymphocytic leukemia b
• chronic myeloid leukemia
• subset t
• clinical case