mSystems
(Jun 2021)
Genomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes
Jehyun Jeon,
Jaehee Lee,
Se-Min Jung,
Jae Hong Shin,
Woon Ju Song,
Mina Rho
Affiliations
Jehyun Jeon
Department of Computer Science, Hanyang University, Seoul, Republic of Korea
Jaehee Lee
Department of Chemistry, Seoul National University, Seoul, Republic of Korea
Se-Min Jung
Department of Chemistry, Seoul National University, Seoul, Republic of Korea
Jae Hong Shin
Department of Computer Science, Hanyang University, Seoul, Republic of Korea
Woon Ju Song
ORCiD Department of Chemistry, Seoul National University, Seoul, Republic of Korea
Mina Rho
ORCiD Department of Computer Science, Hanyang University, Seoul, Republic of Korea
DOI
https://doi.org/10.1128/mSystems.00053-21
Journal volume & issue
Vol. 6,
no. 3
Abstract
Read online
Halogenases are playing an important role as tailoring enzymes in biosynthetic pathways. Flavin-dependent tryptophan halogenases (Trp-FDHs) are among the enzymes that have broad substrate scope and high selectivity.
WeChat QR code
Close
