An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis

Noelle A. Sterling; Jun Young Park; Raehee Park; Seo-Hee Cho; Seonhee Kim

doi:10.1038/s41467-022-35719-y

Nature Communications (Jan 2023)

An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis

Noelle A. Sterling,
Jun Young Park,
Raehee Park,
Seo-Hee Cho,
Seonhee Kim

Affiliations

Noelle A. Sterling: Shriners Hospitals Pediatric Research Center, Department of Neural Sciences, Lewis Katz School of Medicine, Temple University
Jun Young Park: Shriners Hospitals Pediatric Research Center, Department of Neural Sciences, Lewis Katz School of Medicine, Temple University
Raehee Park: Shriners Hospitals Pediatric Research Center, Department of Neural Sciences, Lewis Katz School of Medicine, Temple University
Seo-Hee Cho: Center for Translational Medicine, Department of Medicine, Sydney Kimmel Medical College, Thomas Jefferson University
Seonhee Kim: Shriners Hospitals Pediatric Research Center, Department of Neural Sciences, Lewis Katz School of Medicine, Temple University

DOI: https://doi.org/10.1038/s41467-022-35719-y
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 10

Abstract

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Entosis is a process of cell cannibalism observed in cancer. Here, Sterling and colleagues report that entosis can also play a role in brain development and can contribute to the pathogenesis of microcephaly.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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