Nature Communications (Apr 2016)
Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development
Abstract
The transcription factor Runx2 regulates osteoblast differentiation of mesenchymal stem cells. In this manuscript, the authors, using a specific conditional knock-out mouse model and molecular studies, demonstrate that the mediator subunit MED23 binds to Runx2 and is essential for driving mesenchymal stem cells toward an osteoblast fate.