Nature Communications (Apr 2016)

Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development

  • Zhen Liu,
  • Xiao Yao,
  • Guang Yan,
  • YiChi Xu,
  • Jun Yan,
  • Weiguo Zou,
  • Gang Wang

DOI
https://doi.org/10.1038/ncomms11149
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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The transcription factor Runx2 regulates osteoblast differentiation of mesenchymal stem cells. In this manuscript, the authors, using a specific conditional knock-out mouse model and molecular studies, demonstrate that the mediator subunit MED23 binds to Runx2 and is essential for driving mesenchymal stem cells toward an osteoblast fate.