Nature Communications (Apr 2020)
Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis
- Narges Tajik,
- Michael Frech,
- Oscar Schulz,
- Fabian Schälter,
- Sébastien Lucas,
- Vugar Azizov,
- Kerstin Dürholz,
- Franziska Steffen,
- Yasunori Omata,
- Andreas Rings,
- Marko Bertog,
- Aroldo Rizzo,
- Aida Iljazovic,
- Marijana Basic,
- Arnd Kleyer,
- Stephan Culemann,
- Gerhard Krönke,
- Yubin Luo,
- Klaus Überla,
- Udo S. Gaipl,
- Benjamin Frey,
- Till Strowig,
- Kerstin Sarter,
- Stephan C. Bischoff,
- Stefan Wirtz,
- Juan D. Cañete,
- Francesco Ciccia,
- Georg Schett,
- Mario M. Zaiss
Affiliations
- Narges Tajik
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Michael Frech
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Oscar Schulz
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Fabian Schälter
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Sébastien Lucas
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Vugar Azizov
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Kerstin Dürholz
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Franziska Steffen
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Yasunori Omata
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Andreas Rings
- Department of Nutritional Medicine, University of Hohenheim
- Marko Bertog
- Institute of Cellular and Molecular Physiology, Friedrich-Alexander University Erlangen-Nürnberg
- Aroldo Rizzo
- Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo
- Aida Iljazovic
- Helmholtz Centre for Infection Research
- Marijana Basic
- Institute for Laboratory Animal Science, Hannover Medical School
- Arnd Kleyer
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Stephan Culemann
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Gerhard Krönke
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Yubin Luo
- Department of Rheumatology & Immunology, West China Hospital
- Klaus Überla
- Deutsches Zentrum für Immuntherapie (DZI)
- Udo S. Gaipl
- Department of Radiation Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen
- Benjamin Frey
- Department of Radiation Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen
- Till Strowig
- Helmholtz Centre for Infection Research
- Kerstin Sarter
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Stephan C. Bischoff
- Department of Nutritional Medicine, University of Hohenheim
- Stefan Wirtz
- Deutsches Zentrum für Immuntherapie (DZI)
- Juan D. Cañete
- Departamento de Reumatología, Hospital Clínic de Barcelona e IDIBAPS
- Francesco Ciccia
- Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo
- Georg Schett
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Mario M. Zaiss
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- DOI
- https://doi.org/10.1038/s41467-020-15831-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Intestinal dysbiosis is associated with an ever-growing list of autoimmune diseases. Here the authors show that both mice and humans with autoimmune arthritis can have dysbiosis and barrier leakiness prior to major signs of inflammatory arthritis, and treatment of mice with a zonulin antagonist can limit collagen-induced arthritis.
