ASSESSMENT OF VITAMIN B12 AND HOMOCYSTEINE LEVELS IN PREGNANT WOMEN ADMITTED FOR DELIVERY AND CORD BLOOD SAMPLES OF THEIR NEWBORN BABIES: A MULTICENTER STUDY

Abstract

Objective: Vitamin B12, an essential micronutrient, plays a vital role in various physiological processes, particularly during pregnancy and fetal development. The growing popularity of vegetarian diets and socioeconomic barriers to consuming animal-based products contributes to Vitamin B12 deficiency becoming a global issue. Understanding the B12 status in pregnant women and its potential impact on newborns is of utmost significance as it can have far-reaching implications for both maternal and infant health. This research aims to investigate the vitamin B12 and homocysteine levels in pregnant women admitted for delivery and analyze corresponding cord blood samples from their newborn babies. Methodology: This prospective study was conducted in three tertiary care hospitals and included pregnant women aged ≥16 years admitted for delivery and their newborns ≥34 weeks. The demographic data and the results of complete blood counts performed within the previous 24 hours before birth were recorded. The levels of vitamin B12 and homocysteine were measured in blood samples and cord blood samples taken from pregnant women and their newborns, respectively. The study parameters were compared between the two groups based on the mothers' and babies' homocysteine and B12 levels. Results: The study included 615 Turkish and 217 foreign pregnant women. Anemia affected 36% of pregnant, with a higher frequency in mothers with B12 deficiency. The mean B12 level in pregnant women was 157±75.3 pg/ml, with 14.8% having elevated homocysteine levels. The levels of B12 and homocysteine of the newborns were 234.7±13.2 pg/ml and 9.13±5.75 mol/L, respectively. Vitamin B12 deficiency was found in 48.9% of newborns, while homocysteine levels were slightly elevated or elevated in 19.1%; both findings were significantly more common in babies born to B12-deficient mothers. Conclusion: In our study, vitamin B12 deficiency was significant in pregnant mothers and their neonates, with a substantial connection to cord blood homocysteine levels. Further study is needed to determine the impact of this deficit on mother and newborn health. Implementing approaches to timely detecting Vitamin B12 deficiency and, if necessary, providing adequate Vitamin B12 supplementation during pregnancy could play a pivotal role in enhancing the health and well-being of both the mother and the child.