Association between occupational noise-induced hearing loss and genotoxicity among textile factory workers

Abstract

Abstract Background/aim Hearing loss caused by exposure to noise is still among the most prevalent health risks for industrial workers. This study aims to evaluate the relationship between Shebien El-kom textile factory workers’ occupational noise exposure, genotoxicity, and noise-induced hearing loss. Methods This cross-sectional case–control study was performed in a textile industry in Shebin Elkom, Egypt. The participants of this work were 36 exposed male workers from the spinning section of the textile factory and 36 subjects as the control male group from administrative staff in the same factory, in the age range of 25–45 years. A pure-tone audiometer and portable sound level meter were utilized for the measurement of hearing threshold and noise level, respectively. Genotoxicity was assessed using the Comet assay technique. Results There was no significant difference between both groups regarding age and the mean duration of work was 18.94 ± 4.88 for exposed workers. The average level of noise was 95–105 dB (A). The exposed workers’ mean hearing thresholds for the left and right ears at frequencies between 2000 and 8000 Hz were substantially greater than those of the control group (P 0.05). The exposed workers’ percentage of DNA damage was substantially greater than that of the control group (p < 0.001). Among exposed workers, a positive correlation between DNA damage, the degree of hearing loss, and the duration of time exposed to noise was demonstrated. Conclusion The majority of exposed workers suffered from occupational noise-induced hearing loss. A positive correlation was found between the percentage of DNA damage, duration of exposure to noise, and hearing threshold in exposed workers.

Keywords

• Noise exposure
• Noise-induced hearing loss
• Genotoxicity
• Comet assay
• Oxidative stress
• DNA damage