The structural basis for RNA selectivity by the IMP family of RNA-binding proteins

Jeetayu Biswas; Vivek L. Patel; Varun Bhaskar; Jeffrey A. Chao; Robert H. Singer; Carolina Eliscovich

doi:10.1038/s41467-019-12193-7

Nature Communications (Sep 2019)

The structural basis for RNA selectivity by the IMP family of RNA-binding proteins

Jeetayu Biswas,
Vivek L. Patel,
Varun Bhaskar,
Jeffrey A. Chao,
Robert H. Singer,
Carolina Eliscovich

Affiliations

Jeetayu Biswas: Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
Vivek L. Patel: Department of Radiation Oncology, Massachusetts General Hospital
Varun Bhaskar: Friedrich Miescher Institute for Biomedical Research
Jeffrey A. Chao: Friedrich Miescher Institute for Biomedical Research
Robert H. Singer: Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
Carolina Eliscovich: Department of Anatomy and Structural Biology, Albert Einstein College of Medicine

DOI: https://doi.org/10.1038/s41467-019-12193-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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ZBP1 and IMP2 belong to the IGF2BP family of RNA-binding proteins. Here the authors employed SELEX, NMR spectroscopy and mutagenesis to characterize the RNA-binding preference of ZBP1 and IMP2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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