Profilin 1 deficiency drives mitotic defects and reduces genome stability

Federica Scotto di Carlo; Sharon Russo; Francesc Muyas; Maria Mangini; Lorenza Garribba; Laura Pazzaglia; Rita Genesio; Flavia Biamonte; Anna Chiara De Luca; Stefano Santaguida; Katia Scotlandi; Isidro Cortés-Ciriano; Fernando Gianfrancesco

doi:10.1038/s42003-022-04392-8

Communications Biology (Jan 2023)

Profilin 1 deficiency drives mitotic defects and reduces genome stability

Federica Scotto di Carlo,
Sharon Russo,
Francesc Muyas,
Maria Mangini,
Lorenza Garribba,
Laura Pazzaglia,
Rita Genesio,
Flavia Biamonte,
Anna Chiara De Luca,
Stefano Santaguida,
Katia Scotlandi,
Isidro Cortés-Ciriano,
Fernando Gianfrancesco

Affiliations

Federica Scotto di Carlo: Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” (IGB), National Research Council of Italy (CNR)
Sharon Russo: Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” (IGB), National Research Council of Italy (CNR)
Francesc Muyas: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus
Maria Mangini: Institute for Experimental Endocrinology and Oncology, “G. Salvatore” (IEOS), National Research Council of Italy (CNR)
Lorenza Garribba: Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS
Laura Pazzaglia: IRCCS Istituto Ortopedico Rizzoli, Laboratory of Experimental Oncology
Rita Genesio: Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II
Flavia Biamonte: Department of Experimental and Clinical Medicine, Magna Graecia University
Anna Chiara De Luca: Institute for Experimental Endocrinology and Oncology, “G. Salvatore” (IEOS), National Research Council of Italy (CNR)
Stefano Santaguida: Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS
Katia Scotlandi: IRCCS Istituto Ortopedico Rizzoli, Laboratory of Experimental Oncology
Isidro Cortés-Ciriano: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus
Fernando Gianfrancesco: Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” (IGB), National Research Council of Italy (CNR)

DOI: https://doi.org/10.1038/s42003-022-04392-8
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 15

Abstract

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A detailed characterization of in vitro and in vivo phenotypes of Pfn1 knockout cells demonstrates that loss of this gene results in cytoskeletal alterations, leading to mitotic defects and genome instability.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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