Estrogen Receptor-β Gene Cytosine-Adenine (<i>ESR2</i>-CA) Repeat Polymorphism in Postmenopausal Colon Cancer

Naoko Honma; Tomio Arai; Yoko Matsuda; Yosuke Fukunaga; Masaaki Muramatsu; Shinobu Ikeda; Yuri Akishima-Fukasawa; Noriko Yamamoto; Hiroshi Kawachi; Yuichi Ishikawa; Kengo Takeuchi; Tetuo Mikami

doi:10.3390/ijms24054502

International Journal of Molecular Sciences (Feb 2023)

Estrogen Receptor-β Gene Cytosine-Adenine (<i>ESR2</i>-CA) Repeat Polymorphism in Postmenopausal Colon Cancer

Naoko Honma,
Tomio Arai,
Yoko Matsuda,
Yosuke Fukunaga,
Masaaki Muramatsu,
Shinobu Ikeda,
Yuri Akishima-Fukasawa,
Noriko Yamamoto,
Hiroshi Kawachi,
Yuichi Ishikawa,
Kengo Takeuchi,
Tetuo Mikami

Affiliations

Naoko Honma: Department of Pathology, Faculty of Medicine, Toho University, Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan
Tomio Arai: Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan
Yoko Matsuda: Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan
Yosuke Fukunaga: Gastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Ariake, Koto-ku, Tokyo 135-8550, Japan
Masaaki Muramatsu: Diagnostics and Therapeutics of Intractable Diseases, Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
Shinobu Ikeda: Japan Agency for Medical Research and Development, Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan
Yuri Akishima-Fukasawa: Department of Pathology, Faculty of Medicine, Toho University, Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan
Noriko Yamamoto: Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Ariake, Koto-ku, Tokyo 135-8550, Japan
Hiroshi Kawachi: Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Ariake, Koto-ku, Tokyo 135-8550, Japan
Yuichi Ishikawa: Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Ariake, Koto-ku, Tokyo 135-8550, Japan
Kengo Takeuchi: Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Ariake, Koto-ku, Tokyo 135-8550, Japan
Tetuo Mikami: Department of Pathology, Faculty of Medicine, Toho University, Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan

DOI: https://doi.org/10.3390/ijms24054502
Journal volume & issue: Vol. 24, no. 5
p. 4502

Abstract

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The pathobiological role of estrogen is controversial in colorectal cancer. Cytosine-adenine (CA) repeat in the estrogen receptor (ER)-β gene (ESR2-CA) is a microsatellite, as well as representative of ESR2 polymorphism. Though its function is unknown, we previously showed that a shorter allele (germline) increased the risk of colon cancer in older women, whereas it decreased it in younger postmenopausal women. ESR2-CA and ER-β expressions were examined in cancerous (Ca) and non-cancerous (NonCa) tissue pairs from 114 postmenopausal women, and comparisons were made considering tissue types, age/locus, and the mismatch repair protein (MMR) status. ESR2-CA repeats ESR2-CA genotype and resulting ER-β expression were considered to affect the clinical characteristics (age/locus/MMR status) of colon cancer, supporting our previous findings.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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