Synthesis of 6β-N(5)-Methyl-5,6,7,8-tetrahydro-L-biopterin

Abstract

Summary 6β-N(5)-methyl-5.6J,8-tetrahydro-L-biopterin·2 HC1. a new derivate of biological interest, was synthesized from 6β-5,6,7,8-tetrahydro-L-biopteril·2 HC1 and characterized. The latter compound has been used therapeutically in atypical phenylketonuria for many years. The catalytic reductive methylation with PtO2 /H2 and formaldehyde allowed selective methylation at the N(5) position. The chemical properties and stnlctures of the new compound arc compared with N(5)-methyl-tetrahydropterin and N(5)-methyl-tetrahydrofolate.

Keywords

• 6β-n(5)-methyl-5,6,7.8-tetrahydro-l-biopterin
• catalytic reductive methylation
• 6β-5,6,7,8-tetrahydrol- biopterin
• 6β)-5,6j,8-tetrahydro-l-biopterin
• l-biopterin. n(5)-methyl-5.6.7.8-tetrahydro-pterin
• hyperphenylalaninemia
• phenylketonuria