Nature Communications (Oct 2021)

The flashfm approach for fine-mapping multiple quantitative traits

  • N. Hernández,
  • J. Soenksen,
  • P. Newcombe,
  • M. Sandhu,
  • I. Barroso,
  • C. Wallace,
  • J. L. Asimit

DOI
https://doi.org/10.1038/s41467-021-26364-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Genetic signals from quantitative traits could be a challenge to finemap. Flashfm uses summary-level data in a Bayesian framework to favour shared causal variants and capitalises on information between traits, providing an accurate and efficient joint fine-mapping tool for up to six traits.