The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers

Yabing Liang; Ling Yang; Jingwu Xie

doi:10.3390/cells10082030

Cells (Aug 2021)

The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers

Yabing Liang,
Ling Yang,
Jingwu Xie

Affiliations

Yabing Liang: Inner Mongolia Key Laboratory of Medical Cell Biology, Clinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, China
Ling Yang: Inner Mongolia Key Laboratory of Medical Cell Biology, Clinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, China
Jingwu Xie: Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA

DOI: https://doi.org/10.3390/cells10082030
Journal volume & issue: Vol. 10, no. 8
p. 2030

Abstract

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The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle in cancer therapy. This review focuses on the recent advances in the hedgehog pathway’s roles in drug resistance of gastrointestinal cancers and the novel drugs and strategies targeting hedgehog signaling.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

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Abstract

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