Mesenchymal Stem Cell Injection in Two Patients Suffer From Chronic Discogenic Low Back Pain

Masoud Hashemi; Siamak Moradi; Mehrdad Taheri; Siroos Momenzadeh; Alireza Shoae-Hassani; Ali Ghamari; Hasti Hassani; Mahshid Ghasemi; Ali Solhpour; Payman Dadkhah

doi:10.22037/nbm.v7i4.24886

Novelty in Biomedicine (Jun 2020)

Mesenchymal Stem Cell Injection in Two Patients Suffer From Chronic Discogenic Low Back Pain

Masoud Hashemi,
Siamak Moradi,
Mehrdad Taheri,
Siroos Momenzadeh,
Alireza Shoae-Hassani,
Ali Ghamari,
Hasti Hassani,
Mahshid Ghasemi,
Ali Solhpour,
Payman Dadkhah

Affiliations

Masoud Hashemi: Associate professor of Anesthesiology, Fellowship of Pain Management, Director of Pain Fellowship Program Department of Anesthesiology and Pain Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Siamak Moradi: Fellowship of Pain Management Shohadaye-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mehrdad Taheri: Assistant professor of Anesthesiology, Fellowship of Pain Management Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Siroos Momenzadeh: Associate Professor of Anesthesiology, Fellowship of Pain Management Department of Anesthesiology & Pain, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Alireza Shoae-Hassani: Applied Cell Sciences (Cell Therapy) Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Ali Ghamari: Department of Cell and Molecular Biology, Faculty of Life Sciences North Tehran Branch, Islamic Azad University, Tehran, Iran
Hasti Hassani: Fellowship of Pain Management School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mahshid Ghasemi: Assistant professor of Anesthesiology Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran
Ali Solhpour: Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Payman Dadkhah: Assistant professor of Anesthesiology Fellowship of Pain Management, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.22037/nbm.v7i4.24886
Journal volume & issue: Vol. 8, no. 2
pp. 95 – 97

Abstract

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Background: Discogenic low back pain is one of the leading causes of pain and disability across the world. A growing interest in the area of regenerative medicine, led by an improved understanding of the role of mesenchymal stem cells in tissue homeostasis and repair. Cases Report: We had two patients suffered from chronic discogenic low back pain. They were underwent injection of intra-discal 1.5 cc of Adipose Derived Mesenchymal Stem Cells (ADMSC) and followed up for 6 months. After this period of time, there was a significant reduction in both VAS and ODI scores in patients. Conclusion: These data warrant further studies so that we can enhance our understanding of the other unknown mechanisms, which may exist behind stem cell injection. If the effectiveness of such injection to reduce pain and improve function is shown in the upcoming studies, it may provide a new insight for increasing this method of treatment as a proper option in the near future.

low back pain, pain management, stem cell

Published in Novelty in Biomedicine

ISSN: 2345-3907 (Online)
Publisher: Shahid Beheshti University of Medical Sciences
Country of publisher: Iran, Islamic Republic of
LCC subjects: Medicine: Medicine (General)
Website: http://journals.sbmu.ac.ir/nbm

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