Urinary Neopterin Levels as an Indicator of Disease Activation in Behçet’s Disease

Abstract

Behçet’s Disease (BD) is a multisystem inflammatory disorder characterized by recurrent oral and genital ulcerations with uveitis. Clinical features are the only diagnostic and follow up parameters and there is no unique laboratory test to indicate both diagnosis and disease activity. We studied urinary neopterin levels by using high performance liquid chromatography in 21 consecutive patients with Behçet’s Disease in clinically active (n = 13) and inactive (n = 8) phase of the disease and in 14 healthy controls to investigate the correlation between this immunologic parameter and the disease status. In comparison to inactive phase, significantly higher urinary neopterin levels were found in active period (p<O.05). Mean urinary neopterin levels were 210.83 ± 157.19 vs 138.85 ± 56.99 I-imol neopterin/mol creatinine in active and inactive t1hase respectively (p<O.05). There was no significant difference between inactive phase and control values. In only 2 patients, both active and inactive phase urine neopterin levels could be measured in the same individual and increased neopterin levels were also determined in the active phase of disease. In conclusion, urinary neopterin levels were found to be elevated in active period and can be considered as an active phase marker in BD. Larger study groups with own controls of BD patients and other vasculitic disease controls are required before the final judgement.

Keywords

• neopterin
• behçet’s disease
• high performance liquid chromatography