Case Reports in Gastrointestinal Medicine (Jan 2022)

Mucinous Signet-Cell Adenocarcinoma of the Ileum: A Diagnostic Challenge—Case Report and Review of the Literature

  • Tiago Martins,
  • Jalaluddin Umar,
  • Kevin Groudan,
  • Hariharan S. Bharadwaj,
  • David Desilets

DOI
https://doi.org/10.1155/2022/5703407
Journal volume & issue
Vol. 2022

Abstract

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Malignancies of the small intestine are rare. Signet-ring cell carcinoma (SRCC) is one of the rarest forms of adenocarcinoma that can arise in the small intestines. We present a case of a patient who originally presented with abdominal pain and radiographic findings suggestive of ileal congestion. The ileal biopsy specimens were nonspecific, and the patient began a trial of corticosteroid treatment for suspected Crohn’s disease. A repeat colonoscopy yielded biopsies that were positive for malignancy. The patient then underwent an exploratory laparotomy which led to the diagnosis of SRCC. Given their similar presentations and the extreme rarity of this unusual malignancy, it can be difficult to differentiate between new-onset Crohn’s disease and SRCC. A review of the literature was conducted to provide us with an improved understanding of previously documented cases of SRCC.